Thermo Fisher Scientific CD104 (Integrin beta 4) Recombinant Rabbit Monoclonal Antibody (JM11-06)
CD104 (Integrin beta 4)에 특이적인 재조합 토끼 단클론 항체로, 높은 특이성과 일관된 로트 간 재현성을 제공합니다. Western blot 및 IHC(P)에서 검증되었으며, 인간 및 마우스 시료에 반응합니다. 동물 유래 성분이 없는 포뮬레이션으로 연구용에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM11-06 |
| Immunogen | Recombinant protein within mouse Integrin beta 4 aa 1564–1822 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809885 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
Integrins are heterodimeric transmembrane glycoprotein receptors composed of alpha and beta subunits. Different combinations of these subunits determine ligand-binding specificity. Integrins mediate cell-matrix and cell-cell adhesion, transmitting signals that regulate gene expression and cell growth.
The Integrin beta 4 subunit acts as a receptor for laminins and typically associates with the alpha 6 subunit. It plays a key role in invasive carcinoma biology. Mutations in this gene are linked to epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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