Thermo Fisher Scientific FGFR3 Recombinant Rabbit Monoclonal Antibody (JM110-33)
FGFR3 단백질을 표적으로 하는 Thermo Fisher Scientific의 재조합 토끼 단일클론 항체입니다. 높은 특이성과 일관된 로트 간 품질을 제공하며, WB, IHC, ICC/IF 등 다양한 연구 응용에 적합합니다. 동물 유래 성분이 없는 포뮬레이션으로 생명과학 연구용에 최적화되어 있습니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | 1 publication |
| in situ PLA (PLA) | - | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM110-33 |
| Immunogen | Synthetic peptide within Human FGFR3 aa 30–63 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809897 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broad immunoreactivity due to the rabbit immune repertoire
Target Information
FGFR3 is a member of the FGFR family of receptor tyrosine kinases, which regulate cellular functions such as angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, differentiation, and tissue repair.
FGFR family members differ in ligand affinities and tissue distribution. FGFR3 binds acidic and basic fibroblast growth factors, influencing mitogenesis and differentiation, and plays a role in bone development and maintenance.
Mutations in FGFR3 are associated with craniosynostosis and various skeletal dysplasias. Three alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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