Thermo Fisher Scientific FKBP12 Recombinant Rabbit Monoclonal Antibody (JM11-09)
FKBP12 단백질을 표적으로 하는 재조합 토끼 단클론 항체로 높은 특이성과 민감도를 제공합니다. Western blot 및 Immunocytochemistry에 적합하며, HEK293 세포에서 발현된 IgG 형 항체입니다. 일관된 로트 간 품질과 동물 유래 성분이 없는 제형으로 연구용에 최적화되었습니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Publications: View 1 publication
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
- Publications: View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM11-09 |
| Immunogen | Synthetic peptide within Human FKBP12 (aa 76–108) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C (avoid freeze/thaw cycles). |
| Shipping Conditions | Wet ice |
| RRID | AB_2809888 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages include:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the large rabbit immune repertoire
Target Information
FKBP12 is an immunophilin family protein involved in immunoregulation and protein folding/trafficking. It functions as a cis-trans prolyl isomerase binding FK506 and rapamycin, and interacts with intracellular signaling proteins such as type I TGF-beta receptor. It also coordinates multi-protein complex formation with ryanodine receptor channels.
In mice, deletion of the homologous gene leads to congenital heart disorder known as noncompaction of the left ventricular myocardium.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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