Thermo Fisher Scientific STING1/TMEM173 Monoclonal Antibody (STING1/7435)
인간 STING1/TMEM173 단백질을 인식하는 마우스 모노클로날 항체. Western blot 및 IHC 실험에 적합하며, 단백질 A/G로 정제된 액상 형태. 선천 면역 신호전달 연구용으로 사용.
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Thermo Fisher Scientific STING1/TMEM173 Monoclonal Antibody (STING1/7435)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | STING1/7435 |
| Immunogen | Recombinant fragment (around aa190–290) of human TMEM173 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
STING is a 379-amino-acid signaling protein that plays a key role in innate immune signaling. It activates NF-κB and IRF3 transcription pathways, inducing type I interferon (IFN-α and IFN-β) expression and promoting antiviral responses. STING may function as a translocon and participate in apoptotic signal transduction via association with MHC-II, aiding detection of intracellular viral RNA and B-form DNA. It mediates death signaling through ERK pathway activation and is localized to the endoplasmic reticulum membrane, cell membrane, and mitochondrial outer membrane. STING is ubiquitously expressed across most tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: 340061-MSM5-P0_STING_Q86WV6-1_House_mouse.svg, 340061-MSM5-P0_STING_Q86WV6-1_House_mouse_PDP.jpeg)
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