Thermo Fisher Scientific CD36 Chimeric Recombinant Rabbit Monoclonal Antibody (185-1G2 (B467))
CD36 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 사용 가능. 인간 시료 반응성. HEK293 세포에서 발현된 비결합형 항체로 Protein A 정제. CD36 관련 대사 및 질환 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.03 µg/mL |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 185-1G2 (B467) |
| Immunogen | This antibody was raised by immunizing mice with stimulated human leukocytes. Target family: CD36 (UniProt ID: P16671-1), antigen range: 1–472. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074711 |
Product Specific Information
Specificity:
This antibody is specific against CD36 and recognizes an epitope between amino acids 155–183.
CD36 acts as a receptor for various ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine, and apoptotic cells.
It also serves as a receptor for hepatitis C virus in hepatocytes, facilitating viral entry and mediating uptake of Mycobacterium fortuitum, E. coli, and S. aureus.
Target Information
CD36, also known as scavenger receptor class B member 3, is expressed on macrophages, platelets, and adipocytes.
It plays key roles in lipid metabolism, inflammation, and atherosclerosis, mediating recognition and uptake of oxidized LDL, long-chain fatty acids, and apoptotic cells.
CD36 is implicated in malaria pathogenesis and functions as a receptor for thrombospondin in platelets and various cell lines.
Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants exist.
Diseases associated with CD36 include Platelet Glycoprotein IV Deficiency and Coronary Heart Disease 7.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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