Thermo Fisher Scientific IL-4 Recombinant Rabbit Monoclonal Antibody (19H10L7)

Applications

Western Blot (WB)

• Tested Dilution: 1–2 µg/mL
• Publications: [Reference not available]

Product Specifications

Product Specific Information

• Predicted to react with rat, non-human primate, and rabbit based on sequence homology.
• Intact IgG appears on a non-reducing gel as ~150 kDa band; upon reduction, generates ~25 kDa light chain and ~50 kDa heavy chain bands.
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems derived from immunoreactive rabbit DNA sequences.
• Advantages include:
  • Enhanced specificity and sensitivity
  • Lot-to-lot consistency
  • Animal origin-free formulations
  • Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells and serves as a ligand for the interleukin 4 receptor.
IL-4 exhibits broad biological activity and shares receptor binding with IL-13, leading to overlapping functions.
STAT6 plays a key role in mediating IL-4 signaling.
The IL-4 gene is part of a cytokine gene cluster on chromosome 5q along with IL-3, IL-5, IL-13, and CSF2.
IL-4 and IL-13 are closely located and are co-regulated by long-range regulatory elements spanning approximately 120 kb.
IL-4 delta 2 is a known splice variant of IL-4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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