Thermo Fisher Scientific CD137 Recombinant Mouse Monoclonal Antibody (4B4-1-1)
인간 CD137(4-1BB)에 특이적으로 결합하는 Mouse Recombinant Monoclonal Antibody입니다. IHC, Flow Cytometry, ELISA 등 다양한 면역분석에 사용 가능하며, HEK293 발현 시스템에서 생산되었습니다. Protein A로 정제된 고순도 항체로 연구용으로 적합합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4B4-1-1 |
| Immunogen | Fusion protein of human 4-1BB antigen and glutathione S-transferase (GST) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074764 |
Product Specific Information
This antibody binds specifically to human 4-1BB, which is expressed on the surface of activated T cells.
Target Information
CD137 (also known as TNFRSF9 or 4-1BB) is an inducible costimulatory molecule mainly expressed on activated T cells. Its ligand, 4-1BBL, is found on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling supports the survival and expansion of activated and memory CD8+ T cells while modulating myelopoiesis and dendritic cell development. Triggered CD137 induces cytokine release that regulates peripheral monocyte survival. Soluble CD137 may act as a negative feedback regulator in immune responses.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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