Thermo Fisher Scientific SARS-CoV/SARS-CoV-2 NP Chimeric Recombinant Rabbit Monoclonal Antibody (CR3018 (03-018))

Applications

Immunocytochemistry (ICC/IF)

• Assay-dependent

ELISA

• Tested Dilution: 10,000 ng/mL

Product Specifications

Product Specific Information

Specificity: This antibody binds the amino acid residues between 11–19 of the N protein of SARS-CoV as well as SARS-CoV-2 (COVID-19) nucleocapsid protein.

Target Information

Human coronaviruses are the major cause of upper respiratory tract illness in humans, such as the common cold. Coronaviruses are positive-stranded RNA viruses, featuring the largest viral RNA genomes known to date (27–31 kb). The first step in coronavirus infection is binding of the viral spike protein, a 139-kDa protein, to certain receptors on host cells. The spike protein is the main surface antigen of the coronavirus. The most prominent protein in the culture supernatants infected with SARS virus is a 46 kDa nucleocapsid protein. This suggests that the nucleocapsid protein is a major immunogen that may be useful for early diagnostics. SARS-CoV-2 Nucleocapsid Protein is associated with nucleic acid and is the most abundant protein for coronavirus. Because of the strong immunogenicity of coronavirus Nucleocapsid, it is believed that SARS-CoV-2 Nucleocapsid Protein has potential value for the diagnosis of the virus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.