Thermo Fisher Scientific CD53 Monoclonal Antibody (MEM-53), FITC
인간 CD53 단백질을 인식하는 마우스 단클론 항체로, FITC 형광 표지되어 유세포분석(Flow Cytometry)에 적합. PBS 버퍼와 BSA 함유, 4°C 암소 보관. CD53 관련 신호전달 및 면역세포 연구용.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 20 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-53 |
| Immunogen | Leukocytes of patient suffering from a LGL-type leukemia |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153249 |
Product Specific Information
This antibody reacts with the deglycosylated molecule (molecular weight of the antigen is reduced by 15 kDa using endoglycosidase F).
Target Information
CD53 is a tetraspanin family transmembrane glycoprotein expressed in the lymphoid-myeloid lineage. It forms complexes with leukocyte surface proteins such as CD2, CD19, CD21, MHC II, VLA-4, or tetraspanins CD37, CD81, and CD82, modulating various signaling processes. CD53 is involved in tumor cell radioresistance and has an anti-apoptotic effect when triggered. In the thymus, CD53 is up-regulated during T cell positive selection and is strongly expressed upon macrophage exposure to bacterial lipopolysaccharide, while neutrophil stimulation results in down-regulation of CD53 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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