Thermo Fisher Scientific DFNA5 Polyclonal Antibody
DFNA5 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot과 IHC에 적합합니다. C-말단 합성 펩타이드로부터 유래된 항체이며, Human에 반응합니다. Protein A로 정제되었으며, PBS buffer에 보관됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1.25 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human DFNA5 (aa 401–450) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2610179 |
Product Specific Information
Peptide sequence:
AALLGTCCKL QIIPTLCHLL RALSDDGVSD LEDPTLTPLK DTERFGIVQR
Sequence homology:
Cow: 85%
Dog: 77%
Guinea Pig: 83%
Human: 100%
Rat: 85%
Target Information
DFNA5 (deafness, autosomal dominant 5), also known as ICERE-1, is a 496 amino acid protein expressed in cochlea tissue, placenta, brain, heart, liver, lung, and pancreas as two alternatively spliced isoforms (short and long).
Mutations in DFNA5 cause non-syndromic sensorineural deafness autosomal dominant type 5 (DFNA5), a form of hearing loss due to damage in sound-processing structures of the brain.
The DFNA5 gene is located on human chromosome 7, which contains over 1,000 genes and represents about 5% of the human genome.
Defects in genes on chromosome 7 have been associated with disorders such as Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia, and Shwachman-Diamond syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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