Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBio17B7), PE, eBioscience
Mouse 및 Rat IL-17A를 특이적으로 인식하는 단클론 항체로, Flow Cytometry 및 IHC 등 다양한 응용에 적합. PE 형광표지로 높은 감도와 재현성 제공. 염증성 질환 연구 및 Th17 세포 분석에 유용.
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Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBio17B7), PE, eBioscience™
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | 2 |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | 1 |
| Immunocytochemistry (ICC/IF) | - | 1 |
| Flow Cytometry (Flow) | 0.125 µg/test | 147 |
| ELISA | - | 2 |
| Functional Assay | - | 1 |
| Miscellaneous (PubMed) | - | 2 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Dog, Human, Mouse, Rat |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio17B7 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_763582 |
Available Formats
- Alexa Fluor 488
- APC
- Biotin
- Brilliant UV 395, 615, 661, 737, 805
- Brilliant Violet 421, 650, 711, 786
- eFluor 450, 506, 660
- FITC
- PE-Cyanine7
- PE-eFluor 610
- PerCP-Cyanine5.5
- Custom conjugation available
Product Specific Information
The eBio17B7 antibody reacts with mouse and rat IL-17A without cross-reactivity to IL-17F. IL-17A is a CD4+ T cell-derived cytokine that promotes inflammatory responses and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. It exists as glycosylated 20–30 kD homodimers and enhances ICAM-1 expression in fibroblasts while stimulating epithelial and endothelial cells to secrete IL-6, IL-8, G-CSF, and PGE2.
Applications Reported: Useful for intracellular staining in flow cytometric analysis.
Applications Tested: Validated by intracellular staining of restimulated, Th17-polarized mouse splenocytes using the Intracellular Fixation and Permeabilization Buffer Set (Product #88-8824-00). Recommended ≤0.125 µg/test (100 µL final volume).
Staining Compatibility: Works with Foxp3 buffer system (Product #00-5523-00).
Excitation/Emission: 488–561 nm / 578 nm; compatible with Blue, Green, and Yellow-Green lasers.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a 32 kDa disulfide-linked homodimer consisting of 136 amino acids. It promotes inflammatory responses and signals through IL-17R/CDw217. IL-17A induces IL-6 secretion and regulates NF-κB and MAPK pathways, enhancing COX-2 and nitric oxide production. It plays a key role in autoimmune and inflammatory disease mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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