Thermo Fisher Scientific IRAK1 Monoclonal Antibody (8F1A7)
IRAK1 단백질을 인식하는 단클론 항체로, Western blot 및 IHC에 적합. 인간, 마우스, 랫트 반응성. 단백질 G 정제, 액상 형태, 1 mg/mL 농도. 연구용으로 Toll/IL-1 신호 경로 분석에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 5 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8F1A7 |
| Immunogen | Recombinant protein corresponding to amino acids 618–712 of human IRAK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154024 |
Product Specific Information
A suggested positive control is IRAK recombinant protein.
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. IRAK1 is recruited by MYD88 to the receptor-signaling complex upon TLR activation. Its association with MYD88 leads to phosphorylation by IRAK4, followed by autophosphorylation and activation. IRAK1 can also phosphorylate TIRAP, promoting ubiquitination and degradation. Additionally, IRAK1 phosphorylates interferon regulatory factor 7 (IRF7), inducing its activation and nuclear translocation, which results in transcriptional activation of type I IFN genes, driving antiviral responses.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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