Thermo Fisher Scientific CTCF Monoclonal Antibody (1D11)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-15792 antibody targets CTCF in indirect ELISA and Western blot applications.
It shows reactivity with Human and Non-human primate samples.
The immunogen is a purified recombinant fragment of human CTCF expressed in E. coli.
MA5-15792 detects CTCF with a predicted molecular weight of approximately 83 kDa.

Target Information

CTCF is a ubiquitously expressed transcriptional factor containing 11 zinc finger domains.
It is a DNA-binding nuclear phosphoprotein involved in multiple aspects of gene regulation, including transcriptional repression and activation, gene silencing, chromatin insulation, and regulation of imprinted sites.
CTCF interacts with the CCCTC DNA motif and can associate with HAT- and HDAC-containing complexes, influencing transcriptional activation or repression.
It is involved in transactivation of the APPB gene, silencing of the c-myc gene, insulation of human beta-globin and DMI myotonic dystrophy loci, and imprinting control of IGF2 and H19 regions.
CTCF also regulates transcription of Pax6 and IRAK2 promoters, with potential therapeutic implications.
Mutations in this gene are associated with invasive breast cancers, prostate cancers, and Wilms’ tumors.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.