Thermo Fisher Scientific PD-1 Monoclonal Antibody (7A11B1)
PD-1 단백질을 인식하는 Mouse monoclonal antibody(7A11B1)로, WB, IHC, IHC(P), IP 실험에 사용 가능. Human, Mouse, Rat 반응성. Protein A로 정제된 1 mg/mL 액상 형태. 4°C에서 보관하며, 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 2 publications |
| Immunohistochemistry (IHC) | 20 µg/mL | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5 µg/mL | - |
| Immunoprecipitation (IP) | - | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7A11B1 |
| Immunogen | A ~150 amino acid recombinant protein from near the amino terminus of mouse PD-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152225 |
Product Specific Information
A suggested positive control is PD-1 recombinant protein.
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). Activated T cells express receptors such as PD-1 (PDCD-1) that mediate inhibitory signals from APCs. PD-1 binds to ligands PDL-1 and PDL-2, and upon binding, inhibits immune activation in the absence of danger signals like LPS. PD-1 deficiency in mice results in hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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