Thermo Fisher Scientific CCL3 Recombinant Rabbit Monoclonal Antibody (1H20L19)
인간 CCL3(MIP-1α)를 인식하는 재조합 토끼 단클론 항체. Western blot 및 IHC(P) 검증됨. 높은 특이성과 민감도를 제공하며, 로트 간 일관성 및 동물 유래 성분 무첨가. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1H20L19 |
| Immunogen | Recombinant protein corresponding to amino acids 27–92 of human MIP1-alpha (CCL3, UniProt ID: P10147-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532386 |
Product Specific Information
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generates a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in host responses to bacterial, viral, parasitic, and fungal pathogens by regulating the trafficking and activation of inflammatory cells such as macrophages, lymphocytes, and NK cells.
While both MIP-1α and MIP-1β exert similar effects on monocytes, their effects on lymphocytes differ:
- MIP-1α: selectively attracts CD8+ lymphocytes
- MIP-1β: selectively attracts CD4+ lymphocytes
Additionally, both are potent chemoattractants for B cells, eosinophils, and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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