Thermo Fisher Scientific Sortilin Polyclonal Antibody
Rabbit polyclonal antibody targeting human Sortilin. Validated for WB and IHC at 10–50 µg/mL. Lyophilized, unconjugated form with PBS buffer and no preservative. Ideal for protein transport and receptor studies. For research use only.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | – |
| Immunohistochemistry (IHC) | 10–50 µg/mL | – |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the cytoplasmic domain of human Sortilin conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: Sortilin.
Target Information
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. It is required for protein transport from the Golgi apparatus to lysosomes via a pathway independent of the mannose-6-phosphate receptor (M6PR) and also for transport to endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of proBDNF and proNGFB, and acts as a receptor for neurotensin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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