Thermo Fisher Scientific SATB2 (Colorectal Carcinoma Marker) Recombinant Rabbit Monoclonal Antibody (SATB2/8697R)
휴먼 SATB2 단백질을 인식하는 재조합 토끼 단클론 항체로, 대장암 표지자 연구에 적합합니다. IHC(P) 및 IHC(PFA) 실험에 사용 가능하며, 고순도 Protein A/G 정제 및 안정적 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SATB2/8697R |
| Immunogen | Synthetic peptide corresponding to residues within aa200–300 of human SATB2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
DNA-binding protein SATB2 binds to DNA at nuclear matrix- or scaffold-associated regions and recognizes the sugar-phosphate structure of double-stranded DNA.
SATB2 functions as a transcription factor regulating nuclear gene expression by binding to matrix attachment regions (MARs) and inducing chromatin-loop remodeling.
It acts as a docking site for chromatin remodeling enzymes, recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers.
SATB2 is essential for initiating upper-layer neuron (UL1) genetic programs and repressing deep-layer (DL) and UL2 genes, likely through modulation of BCL11B expression.
It serves as a repressor of Ctip2 and plays a key role in corticocortical connection development in the cerebral cortex.
Mutations in SATB2 are associated with isolated cleft palate (CPI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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