Thermo Fisher Scientific SATB2 (Colorectal Carcinoma Marker) Recombinant Rabbit Monoclonal Antibody (SATB2/8697R)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Target Information

DNA-binding protein SATB2 binds to DNA at nuclear matrix- or scaffold-associated regions and recognizes the sugar-phosphate structure of double-stranded DNA.
SATB2 functions as a transcription factor regulating nuclear gene expression by binding to matrix attachment regions (MARs) and inducing chromatin-loop remodeling.
It acts as a docking site for chromatin remodeling enzymes, recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers.
SATB2 is essential for initiating upper-layer neuron (UL1) genetic programs and repressing deep-layer (DL) and UL2 genes, likely through modulation of BCL11B expression.
It serves as a repressor of Ctip2 and plays a key role in corticocortical connection development in the cerebral cortex.
Mutations in SATB2 are associated with isolated cleft palate (CPI).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.