Thermo Fisher Scientific Phospho-Caveolin 1 (Tyr14) Monoclonal Antibody (M283)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects a 21 kDa protein corresponding to the apparent molecular mass of caveolin-1 on SDS-PAGE immunoblots of human A431 cells treated with EGF or pervanadate, and is not observed in untreated cells.

Target Information

Caveolin-1 (CAV1) is a scaffolding protein located within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. It can bind with DPP4 and induce T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.