Thermo Fisher Scientific IL-12/IL-23 p40 Monoclonal Antibody (eBioHP40 (HP40, HP-40)), eFluor 660, eBioscience
IL-12 및 IL-23 p40 서브유닛을 인식하는 마우스 단클론 항체로, eFluor 660 형광 표지 적용. Flow cytometry용으로 최적화되어 낮은 background를 제공. 4°C 암저장, 동결 금지. 연구용으로만 사용 가능.
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Thermo Fisher Scientific IL-12/IL-23 p40 Monoclonal Antibody (eBioHP40 (HP40, HP-40)), eFluor 660
Applications
- Flow Cytometry (Intracellular staining)
Tested Dilution: 5 µL (0.03 µg)/test
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), eFluor™ 660 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioHP40 (HP40, HP-40) |
| Conjugate | eFluor™ 660 |
| Excitation / Emission Max | 651 / 668 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Wet ice |
| RRID | AB_10597460 |
Additional Formats
- eFluor 450
- PE
- PerCP-eFluor 710
- Request custom conjugation available
Product Specific Information
The eBioHP40 antibody reacts with the p40 subunit of human IL-12 p70 and IL-23.
IL-12 is a 70 kDa heterodimeric cytokine composed of p40 and p35 subunits, secreted mainly by activated monocytes, macrophages, and dendritic cells.
IL-23 is a related heterodimeric cytokine composed of p40 and p19 subunits.
The eBioHP40 antibody shows lower background staining than C8.6 and recognizes a different epitope.
It is validated for intracellular staining followed by flow cytometric analysis and pre-titrated for use at 5 µL (0.03 µg) per test.
A test is defined as staining a cell sample in a final volume of 100 µL (typically 10⁵–10⁸ cells/test).
eFluor® 660 replaces Alexa Fluor® 647, emits at 659 nm, and is excited with a red laser (633 nm).
Ensure instrument compatibility with this fluorochrome.
Excitation: 633–647 nm
Emission: 668 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
IL-12 is produced by dendritic cells, neutrophils, macrophages, and lymphoblastoid cells upon antigenic stimulation.
It is encoded by IL-12A (p35) and IL-12B (p40).
IL-23 shares the IL-12B subunit and includes IL-23A (p19).
Functionally, IL-12 increases endothelial adhesion molecule-1 expression, directs leukocytes toward tumors, and promotes ischemic-hemorrhagic necrosis of tumor tissue.
IL-23 stimulates memory T-cells and is essential for Th17 cell activation and maintenance, contributing to neutrophil chemokine and pro-inflammatory cytokine upregulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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