Thermo Fisher Scientific IL-22 Monoclonal Antibody (22URTI), eFluor 660, eBioscience
인간 IL-22를 인식하는 22URTI 단클론 항체로, eFluor 660 형광체가 결합되어 있습니다. Th17 및 NK 세포의 IL-22 발현 분석에 적합하며, 유세포분석 및 세포내 염색에 사용됩니다. 고순도 정제 및 안정적인 형광 신호 제공.
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Thermo Fisher Scientific IL-22 Monoclonal Antibody (22URTI), eFluor 660, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 5 µL (0.125 µg)/test | View 13 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), eFluor™ 660, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 22URTI |
| Conjugate | eFluor™ 660 |
| Excitation / Emission Max | 651 / 668 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10598650 |
Available Formats
- Brilliant UV 395
- Brilliant UV 563
- Brilliant UV 661
- Brilliant UV 737
- Brilliant UV 805
- Brilliant Violet 421
- Brilliant Violet 605
- eFluor 450
- FITC
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Request custom conjugation
Product Specific Information
Description:
The 22URTI monoclonal antibody reacts with human interleukin (IL)-22, a 20 kDa cytokine of the IL-10 family secreted primarily by Th17 and NK cells. IL-22 expression is induced by IL-23 and serves as an effector cytokine in Th17-mediated immune responses. Its receptor is a heterodimer of IL-10R2 and IL-22R1.
Applications Reported:
Used for intracellular staining followed by flow cytometric analysis.
Applications Tested:
Pre-titrated and tested for intracellular staining and flow cytometry of Th17-polarized human peripheral blood cells. Recommended use: 5 µL (0.125 µg) per test.
Fluorophore Information:
eFluor® 660 replaces Alexa Fluor® 647. Excitation at 633–647 nm, emission at 668 nm, compatible with red laser detection.
Filtration:
0.2 µm post-manufacturing filtered.
Target Information
IL-22 (IL-10-related T-cell derived inducible factor) is part of the IFN–IL-10 cytokine family. It is produced mainly by activated T cells and NK cells, encoded on chromosome 12q. IL-22 signals through IL-22R1 and IL-10R2 receptor complex, activating the JAK-STAT pathway.
It acts primarily on nonimmune cells such as keratinocytes, hepatocytes, and epithelial cells, regulating innate immunity and wound healing. IL-22 expression is elevated in chronic inflammation and plays a key role in host defense against extracellular pathogens.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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