Thermo Fisher Scientific STAT3 Recombinant Rabbit Monoclonal Antibody (BLR098G)
STAT3 단백질을 인식하는 재조합 토끼 모노클로날 항체로, Western blot, IHC, ICC/IF, IP 등에 적합합니다. HEK293 발현 시스템에서 생산되었으며 1 mg/mL 농도의 액상 형태로 제공됩니다. 세포 성장 및 신호전달 연구에 활용 가능합니다.
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Thermo Fisher Scientific STAT3 Recombinant Rabbit Monoclonal Antibody (BLR098G)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | 6 µL / 1 mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR098G |
| Immunogen | Peptide representing a region between residue 175 and 225 of human STAT3 (signal transducer and activator of transcription 3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 7.8–8.6 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2926517 |
Product Specific Information
Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.
Target Information
STAT3 belongs to the family of STAT (signal transducers and activators of transcription) proteins. These proteins are phosphorylated by receptor-associated kinases, translocate to the nucleus, and act as transcription factors in response to cytokines and growth factors. Coactivators such as CREB-binding protein are required for STAT3 activation. STAT3 can be activated by Interferon-alpha, Interferon-gamma, EGF, PDGF, and IL6.
Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for dimer formation, nuclear translocation, and DNA binding. The STAT3 gene is located on chromosome 17q in humans. STAT3 mediates gene expression related to cell growth and apoptosis, and is regulated by Rac1 and inhibited by PIAS3. Three alternatively spliced transcript variants encoding distinct isoforms have been described. Deletion of STAT3 in knockout mice is lethal at the early embryonic stage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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