Thermo Fisher Scientific ZEB1 Monoclonal Antibody (OTI8A2), TrueMAB
인간 ZEB1 단백질(aa 1-350)을 항원으로 하는 Mouse IgG2b 단클론 항체. Western blot에 최적화된 TrueMAB 제품으로 고순도 친화 크로마토그래피 정제. 동결건조 형태로 제공되며, 재구성 및 결합 실험에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8A2 |
| Immunogen | Human recombinant protein fragment (aa 1–350 of human ZEB1) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform additional desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
ZEB1 (Zinc finger E-box-binding homeobox 1) acts as a transcriptional repressor and inhibits IL-2 gene expression. It modulates ATP1A1 promoter activity depending on cDNA amount and cell type, represses E-cadherin promoters, and induces epithelial-mesenchymal transition (EMT) via SMARCA4/BRG1 recruitment.
ZEB1 also represses BCL6 transcription in the presence of CTBP1, positively regulates neuronal differentiation, and suppresses RCOR1 transcription during neurogenesis.
Mutations in ZEB1 are associated with corneal dystrophies including posterior polymorphous and Fuchs endothelial dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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