Thermo Fisher Scientific c-Myc Chimeric Recombinant Rat Monoclonal Antibody (9E10)

Thermo Fisher Scientific c-Myc Chimeric Recombinant Rat Monoclonal Antibody (9E10)

Applications and Tested Dilution

• Western Blot (WB): Assay-dependent
• Immunohistochemistry (Paraffin) (IHC-P): Assay-dependent
• Immunohistochemistry (Frozen) (IHC-F): Assay-dependent
• Immunocytochemistry (ICC/IF): Assay-dependent
• Immunoprecipitation (IP): Assay-dependent

Product Specifications

Product Specific Information

Epitope sequence: EQKLISEEDL, located in aa 410–419 of human c-Myc protein.

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on chromosome 8q24. It is commonly activated in tumor cells and plays a key role in:

• Cellular proliferation, differentiation, apoptosis, and cell cycle progression
• Phosphorylation at Thr58/Ser62 by GSK3, CDK, ERK2, and JNK involved in proliferation regulation
• Vasculogenesis and angiogenesis during tumor development

Amplification or translocation of the c-Myc gene is associated with multiple cancers including lung, breast, colon, and Burkitt’s lymphoma.
Antibodies against c-Myc epitopes recognize overexpressed Myc-tagged proteins fused to amino or carboxy termini.
c-Myc-, N-Myc-, and L-Myc-encoded proteins function in cell proliferation, differentiation, and neoplastic disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: MA5-51740_c-Myc_P01106-2_Rat.svg, MA5-51740_c-Myc_P01106-2_Rat_PDP.jpeg)