Thermo Fisher Scientific c-Myc Chimeric Recombinant Rat Monoclonal Antibody (9E10)
c-Myc 단백질을 인식하는 Rat 유래 재조합 단클론 항체로 다양한 면역학적 분석(WB, IHC, ICC, IP)에 사용 가능. HEK293 세포에서 발현된 IgG2a 형 항체이며, Protein A로 정제됨. 인간 c-Myc의 C-말단 펩타이드(aa 408-439)를 면역원으로 사용. 연구용으로만 사용 가능.
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Thermo Fisher Scientific c-Myc Chimeric Recombinant Rat Monoclonal Antibody (9E10)
Applications and Tested Dilution
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (Paraffin) (IHC-P): Assay-dependent
- Immunohistochemistry (Frozen) (IHC-F): Assay-dependent
- Immunocytochemistry (ICC/IF): Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rat / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9E10 |
| Immunogen | Synthetic peptide corresponding to aa 408–439 from C-terminus of human c-Myc |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C (avoid freeze/thaw cycles). |
| Shipping Conditions | Wet ice |
Product Specific Information
Epitope sequence: EQKLISEEDL, located in aa 410–419 of human c-Myc protein.
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on chromosome 8q24. It is commonly activated in tumor cells and plays a key role in:
- Cellular proliferation, differentiation, apoptosis, and cell cycle progression
- Phosphorylation at Thr58/Ser62 by GSK3, CDK, ERK2, and JNK involved in proliferation regulation
- Vasculogenesis and angiogenesis during tumor development
Amplification or translocation of the c-Myc gene is associated with multiple cancers including lung, breast, colon, and Burkitt’s lymphoma.
Antibodies against c-Myc epitopes recognize overexpressed Myc-tagged proteins fused to amino or carboxy termini.
c-Myc-, N-Myc-, and L-Myc-encoded proteins function in cell proliferation, differentiation, and neoplastic disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: MA5-51740_c-Myc_P01106-2_Rat.svg, MA5-51740_c-Myc_P01106-2_Rat_PDP.jpeg)
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