Thermo Fisher Scientific CDK2 Monoclonal Antibody (OTI2F10), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

CDK2/cyclinO is a member of the cyclin-dependent protein kinase family complexed with CyclinO. CyclinO represents a specific protein isoform of the UNG gene, localized in the nucleus and exhibiting uracil-DNA glycosylase activity. CDK2/cyclinO levels rise during the G1 phase and are degraded throughout the cell cycle. Cyclin A-CDK2 peaks at the G1/S transition, with both proteins associated with DNA in the replication initiation complex. Rb protein serves as a substrate for CDK2-cyclin E and/or CDK2-cyclin A in vivo. CDK2 is activated and localized to the nucleus during late G1, S, and G2 phases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.