Thermo Fisher Scientific CD62P (P-Selectin) Monoclonal Antibody (Psel.KO2.3), PE, eBioscience

Applications and Tested Dilution

• Application: Flow Cytometry (Flow)
• Tested Dilution: 0.25 µg/test
• Publications: View 23 publications

Product Specifications

Available Conjugate Formats:

• APC
• PerCP-eFluor 710
• Super Bright 600
• Request custom conjugation

Product Specific Information

The Psel.KO2.3 monoclonal antibody reacts with mouse CD62P (P-selectin, GMP-140), a 140 kDa cell adhesion molecule induced on endothelial cells and platelets. During inflammation, it mediates adhesion of monocytes and neutrophils to activated platelets and leukocyte rolling on endothelial cells. The antibody recognizes a conserved epitope across multiple species (mouse, human, rat) and does not block cell adhesion.

• Applications Reported: Flow cytometric analysis
• Applications Tested: Tested on thrombin-activated human platelets at ≤0.25 µg/test
• Recommended Use: Optimize antibody titration for best performance
• Excitation: 488–561 nm
• Emission: 578 nm
• Laser Compatibility: Blue, Green, Yellow-Green Laser
• Filtration: 0.2 µm post-manufacturing filtered

Target Information

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type I transmembrane glycoprotein involved in cell rolling and adhesion. It is stored in Weibel-Palade bodies of endothelial cells and α-granules of platelets, and rapidly translocates to the cell surface upon activation by thrombin, histamine, complement 5a, Ca²⁺ ionophores, or ADP. P-selectin mediates interactions between activated endothelial cells or platelets and leukocytes, contributing to inflammation, atherogenesis, thrombosis, and tissue injury. Clinically, it helps distinguish heparin-induced thrombocytopenia with or without thrombosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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