Thermo Fisher Scientific CD44/HCAM Std (Cancer Stem Cell Marker) Monoclonal Antibody (rHCAM/6449)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• 1–2 µg/mL

Product Specifications

Target Information

CD44 cell surface antigen is a 100 kDa type I transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues.
CD44 is a receptor for hyaluronic acid (HA) and participates in cell-cell interactions, adhesion, and migration. It plays roles in lymphocyte activation, recirculation, and homing. CD44 expression may be upregulated in certain carcinomas, potentially linked to metastatic potential.

CD44 is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 at high levels; peripheral B and T cells can upregulate CD44 upon stimulation.
The CD44 gene undergoes complex alternative splicing, resulting in diverse isoforms with distinct functions. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 may also be implicated in tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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