Thermo Fisher Scientific CD44/HCAM Std Monoclonal Antibody (SPM521)

Applications and Tested Dilutions

Product Specifications

Target Information

CD44 cell surface antigen is a 100 kDa type I transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues.

CD44 functions as a receptor for hyaluronic acid (HA) and plays roles in cell-cell interactions, adhesion, and migration. It participates in lymphocyte activation, recirculation, and homing. Expression may be upregulated in certain carcinomas, potentially related to metastatic potential.

CD44 is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate CD44 expression in response to stimulatory events.

Transcripts for the CD44 gene undergo complex alternative splicing, resulting in multiple functionally distinct isoforms. This splicing contributes to the structural and functional diversity of the CD44 protein.

Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 may also be implicated in tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.