Thermo Fisher Scientific CD44/HCAM Std (Cancer Stem Cell Marker) Monoclonal Antibody (rHCAM/6449)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• 1–2 µg/mL

Product Specifications

Target Information

CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, adhesion, and migration. It participates in lymphocyte activation, recirculation, and homing. CD44 expression can be up-regulated in certain carcinomas and may be related to metastatic potential.

CD44 is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate CD44 expression upon stimulation. Alternative splicing of CD44 transcripts yields multiple isoforms with distinct functions, contributing to structural and functional diversity. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus, and CD44 may be implicated in tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.