Thermo Fisher Scientific ALK (Anaplastic Lymphoma Kinase)/CD246 Monoclonal Antibody (ALK/1504)
ALK 단백질을 표적하는 Mouse monoclonal antibody로, IHC, ICC, Flow Cytometry 등에 사용 가능. 인간 시료 반응성. 단백질 A/G 정제, PBS buffer에 보존. 뇌 발달 및 종양 관련 ALK 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 0.5–1 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.5–1 µg/mL |
| Flow Cytometry (Flow) | 0.5–1 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ALK/1504 |
| Immunogen | Recombinant human ALK protein fragment (aa 200–335) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been identified in tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangements involving ALK often result in a fusion gene with nucleophosmin (NPM), producing the oncogenic NPM-ALK fusion protein. ALK encodes a receptor protein-tyrosine kinase with a transmembrane and extracellular domain, showing high sequence similarity to LTK. It plays a crucial role in neuronal development and signaling within the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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