Thermo Fisher Scientific CASPASE 1 P10 (CLEAVED ALA317) Polyclonal Antibody
Caspase-1 활성화 단편(Ala317 근처 절단)을 검출하는 Rabbit Polyclonal Antibody. WB, IHC, ICC 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. 고순도 Affinity chromatography 정제, 안정적 PBS/glycerol 저장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CASP1 (Accession P29466), corresponding to amino acid residues T310–S332 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816522 |
Product Specific Information
Antibody detects endogenous levels of fragment of activated Caspase-1 resulting from cleavage adjacent to Ala317.
Target Information
Caspase-1 (CASP1) is a thiol protease that cleaves IL-1 beta between Asp and Ala, releasing the mature cytokine involved in inflammatory processes. CASP1 is important for defense against pathogens and activates sterol regulatory element binding proteins (SREBPs). It also promotes apoptosis. Upon inflammasome activation during DNA virus infection (but not RNA virus challenge), CASP1 controls antiviral immunity through cleavage of CGAS, rendering it inactive.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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