Thermo Fisher Scientific Phospho-DKK1 (Ser140) Polyclonal Antibody
Phospho-DKK1 (Ser140) 폴리클로날 항체로 인간 및 생쥐 시료에서 인산화된 DKK1 단백질 검출에 적합. Western blot에 사용 가능하며 고순도 정제. PBS/glycerol 완충액에 보관, 연구용으로만 사용.
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Applications
Tested Application
- Western Blot (WB): 1:500–1:2,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DKK1 (Accession O94907), corresponding to amino acid residues around phosphorylated Ser140 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816524 |
Product Specific Information
Antibody detects endogenous levels of DKK1 only when phosphorylated at Ser140.
Target Information
DKK-1 is a member of the DKK protein family which includes DKK-2, DKK-3, and DKK-4.
Originally identified as a Xenopus head-forming molecule, DKK-1 acts as an antagonist for Wnt signaling.
DKK-1 and DKK-4 regulate the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LRP5 and LRP6, which serve as co-receptors for Wnt ligands.
Inhibition of Wnt/β-catenin signaling by DKK-1 is essential for anterior development in vertebrates.
Mice deficient in DKK-1 expression lack head formation and die during embryogenesis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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