Thermo Fisher Scientific P16INK4a Recombinant Rabbit Monoclonal Antibody (CDKN2A/8196R)
Recombinant rabbit monoclonal antibody targeting human p16INK4a (CDKN2A). Validated for IHC applications. Produced in HEK293 cells, purified via Protein A/G, and supplied as liquid at 200 µg/mL. Suitable for tumor suppressor and cell cycle research.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
- Immunohistochemistry (PFA fixed) (IHC (PFA)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CDKN2A/8196R |
| Immunogen | Purified recombinant prokaryotic full-length human p16INK4a protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The CDKN2A (p16INK4a) gene produces multiple transcript variants differing in their first exons.
Two isoforms act as inhibitors of CDK4 kinase, while another variant encodes an alternate open reading frame (ARF) that stabilizes the tumor suppressor protein p53 by interacting with MDM2, preventing p53 degradation.
Despite structural differences, these variants share a role in regulating cell cycle G1 progression through CDK4 and p53 pathways.
CDKN2A is frequently mutated or deleted in various tumors and functions as a critical tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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