Thermo Fisher Scientific P16INK4a Recombinant Rabbit Monoclonal Antibody (CDKN2A/8223R)
인간 p16INK4a 단백질을 인식하는 재조합 토끼 단클론 항체로, IHC(P) 및 IHC(PFA) 실험에 적합합니다. 높은 특이성과 재현성을 제공하며, Protein A/G 정제 및 PBS 버퍼에 보존됩니다. 암 연구 및 세포주기 조절 관련 연구에 활용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CDKN2A/8223R |
| Immunogen | Purified recombinant prokaryotic full-length human p16INK4a protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
This gene generates several transcript variants differing in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms functioning as inhibitors of CDK4 kinase. Another transcript includes an alternate first exon located 20 Kb upstream, encoding an ARF protein that stabilizes tumor suppressor p53 by interacting with MDM2. Despite structural and functional differences, both CDK inhibitor isoforms and the ARF product share a common role in cell cycle G1 control. This gene is frequently mutated or deleted in various tumors and is an important tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: 1029-RBM16-P1ABX_p16INK4a_P42771-1_Rabbit.svg, 1029-RBM16-P1ABX_p16INK4a_P42771-1_Rabbit_PDP.jpeg)
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