Thermo Fisher Scientific P16INK4a Recombinant Rabbit Monoclonal Antibody (CDKN2A/7660R)
Human p16INK4a 단백질을 인식하는 재조합 토끼 단클론 항체로, IHC(P) 및 IHC(PFA) 실험에 적합합니다. 높은 특이성과 재현성을 제공하며, Protein A/G로 정제된 액상 형태로 공급됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- 1029-RBM10-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific P16INK4a Recombinant Rabbit Monoclonal Antibody (CDKN2A/7660R)
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CDKN2A/7660R |
| Immunogen | Purified recombinant prokaryotic full-length human p16INK4a protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein structurally unrelated to the other variants. This ARF product stabilizes tumor suppressor protein p53 by interacting with and sequestering the E3 ubiquitin-protein ligase MDM2, which mediates p53 degradation. Despite structural and functional differences, the CDK inhibitor isoforms and ARF product share a common role in cell cycle G1 control through CDK4 and p53 regulation. This gene is frequently mutated or deleted in various tumors and serves as an important tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: 1029-RBM10-P0_p16INK4a_P42771-1_Rabbit.svg / 1029-RBM10-P0_p16INK4a_P42771-1_Rabbit_PDP.jpeg)
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