Thermo Fisher Scientific Phospho-beta Catenin (Ser37) Polyclonal Antibody
Phospho-beta Catenin (Ser37) 항체로, 인산화된 Ser37 부위의 β-Catenin을 특이적으로 검출합니다. Western blot, IHC, ICC/IF에 적합하며, 인간, 마우스, 랫트 시료에 반응합니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CTNNB1 (Accession P35222), corresponding to amino acid residues around phosphorylated Ser37 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816344 |
Product Specific Information
This antibody detects endogenous levels of beta Catenin only when phosphorylated at Serine 37.
Target Information
Beta-catenin is an adherens junction (AJ) protein that plays a crucial role in cell-cell adhesion and signaling. It interacts with E-cadherin and alpha-catenin to link cell adhesion complexes to the actin cytoskeleton. Beyond structural roles, beta-catenin participates in signaling pathways such as Wnt/Wingless, influencing morphogenesis and cell proliferation. Aberrant beta-catenin activity is implicated in various cancers, including colorectal, ovarian, and breast cancer, as well as in tumor development. In the nucleus, it co-activates Lef/Tcf transcription factors to promote expression of genes like cyclin D and c-myc.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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