Thermo Fisher Scientific NEDD4 Monoclonal Antibody (OTI6E12), TrueMAB
인간 NEDD4 단백질(aa 160-460)에 특이적인 mouse monoclonal antibody. Western blot에 최적화됨. 동결건조 형태로 제공되며, PBS buffer와 trehalose 포함. 연구용으로만 사용 가능.
- 카탈로그번호
- CF812646
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific NEDD4 Monoclonal Antibody (OTI6E12), TrueMAB
Applications
- Western Blot (WB): 1:500 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6E12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 160–460 of human NEDD4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a ubiquitin-like (Ubl) conjugation pathway protein containing one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains.
It participates in the degradation pathway of VEGFR-2/KDFR independently of ubiquitin-ligase activity and acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination.
NEDD4 is also implicated in viral budding and regulation of epithelial Na⁺ channels, contributing to arterial hypertension.
The protein localizes to the sarcolemmal region of muscle fibers, and its increased expression is associated with muscle unloading and denervation, leading to decreased Notch1 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.