Thermo Fisher Scientific cAbl Polyclonal Antibody
c-Abl 단백질 인식용 Rabbit Polyclonal Antibody로, WB, IHC, ICC, IP 등 다양한 응용에 사용 가능. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 4°C 보관, 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 550 and 600 of human v-abl Abelson murine leukemia viral oncogene homolog 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response. Its activity is negatively regulated by the SH3 domain; deletion of this domain converts c-Abl into an oncogene. The DNA-binding activity of ABL1 is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. In chronic myelogenous leukemia and some acute lymphoblastic leukemias, c-Abl undergoes a (9;22) chromosomal translocation forming the Philadelphia chromosome, resulting in a fusion with the Bcr gene. The c-Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV) and may regulate DNA repair by activating proapoptotic pathways when DNA damage is irreparable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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