Thermo Fisher Scientific cAbl Polyclonal Antibody
Thermo Fisher Scientific의 cAbl Polyclonal Antibody는 인간 c-Abl 단백질을 인식하는 고품질 Rabbit IgG 항체입니다. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 850 and 900 of human v-abl Abelson murine leukemia viral oncogene homolog 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response. The c-Abl protein activity is negatively regulated by its SH3 domain; deletion of this domain converts c-Abl into an oncogene. c-Abl’s DNA-binding activity is regulated by CDC2-mediated phosphorylation, indicating a role in the cell cycle. In chronic myelogenous leukemia and some acute lymphoblastic leukemias, a (9;22) translocation forms the Philadelphia chromosome, fusing c-Abl sequences with the Bcr gene. c-Abl was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV) and is implicated in DNA repair and apoptosis when DNA damage is irreparable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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