Thermo Fisher Scientific Phospho-Tyrosine Hydroxylase (Ser19) Polyclonal Antibody
Tyrosine Hydroxylase의 Ser19 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF에 사용 가능하며 사람, 마우스, 랫트 반응성. 액상 형태, 1 mg/mL 농도, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human Tyrosine Hydroxylase (UniProt P07101), corresponding to amino acid residues around phosphorylated Ser19 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816235 |
Product Specific Information
This antibody detects endogenous levels of Tyrosine Hydroxylase only when phosphorylated at Serine 19.
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters such as dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with the cofactor tetrahydrobiopterin (BH4), which binds to the catalytic domain and activates enzymatic activity.
Human TH has four splice variants (hTH1–hTH4) that share identical catalytic domains but differ in their N-terminal regulatory regions. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a key role in adrenergic neuron physiology.
TH is associated with several neuropathogenic and cardiovascular diseases, including Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and various heart-related disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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