Thermo Fisher Scientific Phospho-Tyrosine Hydroxylase (Ser31) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of Tyrosine Hydroxylase only when phosphorylated at Serine 31.

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters such as dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with the cofactor tetrahydrobiopterin (BH4), which binds to the TH catalytic domain to activate the enzyme.
In humans, four TH mRNA splice variants (hTH1–hTH4) have been identified, sharing the catalytic domain but differing in their N-terminal regulatory domains. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a key role in adrenergic neuron physiology.
Alterations in TH function are associated with neurological and cardiovascular diseases such as Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and others.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.