Thermo Fisher Scientific Phospho-CDK1 (Tyr15) Polyclonal Antibody
CDK1의 Tyr15 인산화 형태를 특이적으로 인식하는 폴리클로날 항체. Western blot 및 면역형광에 적합. Human, Mouse, Rat 반응성. 고순도 정제 및 안정한 액상 포맷으로 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CDK1 (Accession P06493), corresponding to amino acid residues around phosphorylated Tyr15 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816233 |
Product Specific Information
This antibody detects endogenous levels of CDK1/CDC2 only when phosphorylated at Tyrosine 15.
Target Information
CDK1 (Cell Division Control protein 1) is essential for the completion of START, the controlling event in the cell cycle required to initiate mitosis. It functions as the catalytic subunit of the M-Phase Promoting Factor (MPF), which induces entry into mitosis and is conserved among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays apoptosis onset. CDK inhibitors such as NU2058 have shown therapeutic potential in androgen-independent prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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