Thermo Fisher Scientific GFR alpha-1 Recombinant Rabbit Monoclonal Antibody (029)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

This antibody has specificity for Rat GFRA1.

Target Information

Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nervous system. Physiological responses to GDNF require the presence of a glycosylphosphatidylinositol-linked protein, GDNFRα, which serves as a cell surface receptor for GDNF.

The cDNAs encoding GDNFRα from human, rat, chicken, and mouse have been cloned. GDNFRα, also known as Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1), has been designated as GFRα-1. GFRα-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Together, GDNF, GFRα, and Ret PTK form a complex to transduce GDNF signaling and mediate its biological function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.