Thermo Fisher Scientific TIM3 Recombinant Rabbit Monoclonal Antibody (024)

Applications and Tested Dilution

• ELISA (ELISA): 1:5,000–1:10,000

Product Specifications

Additional Formats

• Biotin Conjugate
• Request custom conjugation

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to the large rabbit immune repertoire

This antibody has specificity for Human TIMD3/HAVCR2.

Target Information

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid, Type-I Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4⁺Th1 and CD8⁺Tc1 cells.
TIM3 contains an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region. It is involved in macrophage activation and induction of autoimmune diseases.

TIM3 down-regulates aggressive Th1-mediated immune responses and contributes to immune tolerance development. Pathological significance includes roles in experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, where TIM3 enhances disease severity in mice.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.