Thermo Fisher Scientific TIM-1 Recombinant Rabbit Monoclonal Antibody (601)

Applications

ELISA (ELISA)

• Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin–free formulation
• Broad immunoreactivity due to the rabbit immune repertoire

This antibody specifically recognizes Rat KIM-1/TIM1/HAVCR1.

Target Information

CD365 (T-cell immunoglobulin and mucin domain 1, Tim-1)
CD365 is a type I surface glycoprotein containing an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail. Its endogenous ligand is Tim-4.

CD365 functions as a receptor or co-receptor for several viruses, including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus. Viral binding occurs via phosphatidylserine on viral envelopes.

Polymorphisms in the human CD365 gene (HAVCR1) are associated with infection susceptibility and disease severity. CD365 is involved in T-cell co-stimulation and is primarily expressed in epithelial cells, as well as in A549, 769-P, and Caco-2 cell lines. Soluble forms can be generated through metalloproteinase-mediated cleavage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.