
Thermo Fisher Scientific CD19 Monoclonal Antibody (1D3)
CD19 단백질을 인식하는 Rat IgG2a 단일클론 항체로, Flow Cytometry, IHC(F), IP, Functional Assay 등 다양한 실험에 사용 가능. Low endotoxin, azide-free PBS 용액으로 제공되며, 4°C에서 보관. 마우스 CD19 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent | - |
| Flow Cytometry (Flow) | 1–4 µg/mL | 6 publications |
| Immunoprecipitation (IP) | Assay-Dependent | - |
| Functional Assay (Functional) | Assay-Dependent | - |
Product Specifications
| Category | Specification |
|---|---|
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D3 |
| Immunogen | Mouse CD19-transfected cell line |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155840 |
Product Specific Information
- Low endotoxin, azide-free phosphate buffered saline (PBS) solution
- 0.2 µm filter sterilized
- Endotoxin level: < 0.01 EU/µg protein (LAL test)
- Functional Application: Induction
Target Information
CD19 is a member of the immunoglobulin superfamily with two Ig-like domains. It is expressed on 100% of peripheral B cells defined by kappa or lambda light chain expression. CD19 is also found on certain myeloid leukemia cells, especially those of monocytic lineage.
CD19 is the earliest and broadest B cell–restricted antigen and serves as a key regulator of normal and malignant B cell proliferation. It functions as a signal-amplifying coreceptor for the B cell receptor (BCR) and can also signal independently. Mutations in CD19 can lead to hypogammaglobulinemia, while overexpression causes B cell hyperactivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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