Thermo Fisher Scientific CD2 Monoclonal Antibody (LT2), PE
인간 CD2 항원에 특이적인 LT2 클론 단일클론 항체로, PE 형광체로 결합되어 T 림프구 및 NK 세포의 표면 CD2 검출에 적합합니다. Flow Cytometry에 최적화되어 있으며, 565/576 nm의 형광 특성을 가집니다. 연구용으로만 사용됩니다.
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Applications
- Flow Cytometry (Flow): 20 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LT2 |
| Immunogen | Normal human blood lymphocytes |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153947 |
Additional Formats
- Unconjugated
- APC
- FITC
- Custom conjugation available upon request
Product Specific Information
This antibody reacts with an extracellular epitope of CD2, a 50 kDa glycoprotein present on human peripheral blood T lymphocytes and NK cells; also expressed by all thymocytes.
Target Information
CD2 (LFA-2) is a monomeric surface antigen (MW range 45–58 kDa) expressed on all peripheral blood T cells. It is one of the earliest T-cell markers, found on over 95% of thymocytes and some NK cells, but not on B lymphocytes.
Monoclonal antibodies against CD2 inhibit rosette formation with sheep erythrocytes, indicating CD2’s role as or association with the erythrocyte receptor. The CD2–CD58 interaction stabilizes adhesion between T cells and antigen-presenting or target cells.
T cell activation increases CD2 expression and mobility, enhancing contact with CD58 and strengthening intercellular adhesion. CD2 deficiency is associated with reduced intestinal inflammation and altered immune control.
Diseases linked to CD2 dysfunction include penile squamous cell carcinoma and immune deficiency due to thymus absence.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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