Thermo Fisher Scientific CD107a (LAMP-1) Monoclonal Antibody (eBio1D4B (1D4B)), eFluor 450, eBioscience
마우스 CD107a(LAMP-1) 인식 단클론 항체로 eFluor 450 형광체 결합 제품. Flow cytometry 및 intracellular staining에 적합하며, 405/445 nm 파장에서 검출 가능. 암 전이 및 리소좀 관련 질환 연구에 유용한 연구용 시약.
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Thermo Fisher Scientific CD107a (LAMP-1) Monoclonal Antibody (eBio1D4B (1D4B)), eFluor 450
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | - | View 7 publications |
| Flow Cytometry (Flow) | 0.5 µg/test | View 9 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), eFluor™ 450 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio1D4B (1D4B) |
| Conjugate | eFluor™ 450 |
| Excitation / Emission Max | 405 / 445 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11219267 |
Additional Formats Available
- Unconjugated
- Alexa Fluor 488
- APC-eFluor 780
- Biotin
- Brilliant Violet 711
- eFluor 660
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Request custom conjugation
Product Specific Information
The eBio1D4B monoclonal antibody reacts with mouse CD107a (LAMP-1), a type I lysosomal membrane protein that is extensively glycosylated. CD107a is constitutively expressed in late endosomes and lysosomes of all cells, and transiently appears on the surface of degranulating cytolytic T cells. It is implicated in cancer metastasis and serves as a marker for lysosomal storage disorders.
Applications Reported:
For intracellular staining followed by flow cytometric analysis.
Applications Tested:
Validated for intracellular staining and flow cytometric analysis of mouse thioglycolate-elicited peritoneal exudate cells. Recommended ≤0.5 µg/test (100 µL final volume). Optimal antibody titration is advised.
Fluorophore Information:
eFluor™ 450 is excited at 405 nm and emits at 445 nm (Violet laser). Alternative to Pacific Blue™. Ensure instrument compatibility.
Filtration:
0.2 µm post-manufacturing filtered.
Target Information
LAMP1 (CD107a) is a major lysosomal membrane protein involved in lysosome biogenesis and fusion with phagosomes. It contains multiple glycosylation sites and a short cytosolic tail. Upon activation, LAMP1 translocates to the plasma membrane via a tyrosine-based motif (YXXI). Aberrant localization affects lysosome trafficking. Surface LAMP1 promotes PBMC adhesion to endothelium, suggesting involvement in inflammation. Elevated LAMP1 is noted in Alzheimer’s disease and mast cell activation studies.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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