Thermo Fisher Scientific AF9 Polyclonal Antibody
Rabbit polyclonal antibody targeting human AF9 (MLLT3) protein. Validated for Western blot and immunoprecipitation. Unconjugated liquid form with 0.20 mg/mL concentration. Suitable for research use only, stored at 4°C and shipped on wet ice.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 200–250 of human ALL1 Fused Gene from Chromosome 9 Protein (MLLT3, Myeloid/Lymphoid or Mixed-Lineage Leukemia Translocate 3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The human AF9 gene is one of the most common fusion partner genes with the ALL1 (MLL) gene at 11q23, resulting in the translocation t(9;11)(p22;q23).
AF9 spans more than 100 kb and includes two patient breakpoint cluster regions (BCRs):
- BCR1: within intron 4 (site A)
- BCR2: spans introns 7 and 8 (site B)
Several structural elements have been identified in AF9:
- DNA topo II cleavage site and DNase I hypersensitive site in intron 7 (BCR2)
- Two scaffold-associated regions (SARs): SAR1 (intron 4) and SAR2 (exons 5–7)
These structural features are shared with the MLL breakpoint cluster region, supporting a DNA breakage and repair model for nonhomologous recombination between MLL and AF9.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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