Thermo Fisher Scientific WNK1 Polyclonal Antibody
Thermo Fisher Scientific의 WNK1 Polyclonal Antibody는 인간 WNK1 단백질을 인식하는 토끼 유래 다클론 항체입니다. Western blot 및 면역침강(IP)에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 전해질 항상성 연구에 유용합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1625 and 1675 of Human WNK lysine deficient protein kinase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
WNK1 serine/threonine kinase is a member of the WNK subfamily. WNK1 may be a key regulator of blood pressure by controlling sodium and chloride ion transport. Mutations in this gene are associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II.
WNK1 plays an important role in electrolyte homeostasis, cell signaling, survival, and proliferation. It acts as both activator and inhibitor of sodium- and potassium-coupled chloride cotransporters, respectively, and activates SCNN1A, SCNN1B, SCNN1D, and SGK1.
WNK1 localizes to the distal nephron, a kidney segment involved in salt, potassium, and pH homeostasis. Mutations in WNK genes result in pseudohypoaldosteronism and neuropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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