Thermo Fisher Scientific Astrin/MAP126 Polyclonal Antibody
Astrin/MAP126 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 사용 가능. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 4°C 보관, 연구용 전용 제품.
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Applications
- Western Blot (WB): Assay-dependent
- Immunoprecipitation (IP): 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of human astrin (mitotic spindle associated protein p126) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
SPAG5 (sperm associated antigen 5), also known as MAP126, hMAP126, DEEPEST, or Astrin, is a 1,193 amino acid protein expressed highly in testis and at lower levels in liver, placenta, pancreas, colon, and thymus.
It localizes to spindle poles during prophase and throughout the spindle during metaphase and anaphase, playing a crucial role in spindle formation and mitotic regulation.
SPAG5 is involved in sister chromatid cohesion, chromatid separation, and chromosome integrity. It forms a homodimer with a long stalk and globular head domain, creating aster-like structures. Upon DNA damage, SPAG5 may be phosphorylated by ATR or ATM.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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